mouse monoclonal IgG2a; FARP2 Antibody (H-9) is an IgG2a κ mouse monoclonal FARP2 antibody (also designated PLEKHC3 antibody or FIR antibody) that detects the FARP2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. FARP2 Antibody (H-9) is available as both the non-conjugated anti-FARP2 antibody form, as well as multiple conjugated forms of anti-FARP2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.