Animal-Free Recombinant Human TGF-alpha

DESCRIPTION

TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-alpha induces anchorage-independent transformation in cultured cells. Human, murine and rat TGF-alpha are cross-species reactive. Recombinant Human TGF-alpha is a 50 amino acid polypeptide (5.5 kDa), which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.

DETAILS

Gene Id: 7039
Uniprot: P01135
Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
Category: RUO Cytokines
Subcategory: Animal-Free Cytokines
Research Areas: Angiogenesis/Cardiovascular, Cancer, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation, Wound Healing
Alternative Names: Transforming Growth Factor-alpha, Sarcoma growth factor, TGF-type I, ETGF
Species of Origin: Human
Expression System Source: E.coli