DESCRIPTION

• Target: FNIP1
• Gene Id: 96459
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide from the mid-protein of Human FNIP1
• References: 1. Woodford, M. R. et al. (2016) Nature Com. 12037. 2. Baba, M. et al. (2006) Proc Natl Acad Sci U.S.A. 103(42):15552-7. 3. www.uniprot.org/uniprot/Q8TF41
• Swiss-prot: Q8TF40
• Specificity: Detects ~130 kDa.
• Applications: WB | ICC/IF | IHC
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Rabbit
• Product Type: Polyclonal
• Purification: Peptide Affinity Purified
• Concentration: 1 mg/ml
• Research Areas: Cancer | Cell Cycle | mTOR Pathway | Cancer | Autophagy
• Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_001008738.2
• Alternative Names: FNIP1 Antibody, Folliculin-interacting protein 1 Antibody, Folliculin interacting protein 1 Antibody, KIAA1961 Antibody
• Antibody Dilution: WB (1:1000); ICC/IF (1:100); IHC (1:50); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SPC-718D, RRID: AB_2706113
• Immunogen Species: Human
• Tissue Specificity: Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
• Storage Temperature: -20ºC
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Cytoplasm
• Scientific Background: Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).
• Certificate of Analysis: A 1:1000 dilution of SPC-718 was sufficient for detection of FNIP1 in 15 µg of mouse kidney cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat

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