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E1019Hu

Human Hepcidin, HEPC ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed: 22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed: 11113131, PubMed: 11034317).

DETAILS

  • GeneID: 57817
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 9,408
  • Synonyms: HEPC;Hepc20;Hepc25;Hepcidin;Hepcidin-20;Hepcidin-25;LEAP-1;Liver-expressed antimicrobial Peptide 1;PLTR;Putative liver tumor regressor
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: HEPC
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 5.12pg/ml
  • Target Protein: HEPC
  • Detection Range: 10-4000pg/ml
  • Full Product Name: Hepcidin
  • Standard Solution: 4800pg/ml
  • UniProt Accession: P81172