100506658-MSM3-P0 100506658-MSM3-P1 100506658-MSM3-P1ABX
Occludin (OCLN) (Tight Junctions Marker) - CloneID - OCLN/2183
NeoBiotechnologies
DESCRIPTION
Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
DETAILS
- Host: Mouse
- Gene ID: 100506658
- Uniprot: Q16625
- Clone ID: OCLN/2183
- Clonality: Monoclonal
- Gene Name: OCLN
- Supplied As: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Applications: IHC
- Protein Target: OCLN
- Species Reactivity: Human
- Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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