Anti-PDIA6 Antibody [JF0974]

DESCRIPTION

Endoplasmic reticulum proteins (ERps) are widely expressed proteins that localize to the ER and may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases or phospholipases. ERp5, also known as PDIA6 (protein disulfide isomerase family A, member 6) or TXNDC7 is a 440 amino acid protein that contains two thioredoxin domains and belongs to the protein disulfide isomerase family. Localized to the melanosome, as well as to the lumen of the endoplasmic reticulum, ERp5 functions to catalyze the rearrangement of disulfide bonds in a variety of different proteins. Via its catalytic activity, ERp5 is able to reduce the disulfide bond that binds MICA to tumor cells, thereby releasing MICA and reducing the rate of tumor expansion. Multiple isoforms of ERp5 exist due to alternative splicing events.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: Q15084 Human;SwissProt: Q922R8 Mouse;SwissProt: Q63081 Rat
Clone Id: JF0974
Clonality: Recombinant Rabbit monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: Endoplasmic reticulum protein 5 antibody ER protein 5 antibody ERp5 antibody P5 antibody Pdia6 antibody PDIA6_HUMAN antibody Protein disulfide isomerase A6 antibody Protein disulfide isomerase associated 6 antibody Protein disulfide isomerase family A member 6 antibody Protein disulfide isomerase P5 antibody Protein disulfide isomerase related protein antibody Protein disulfide-isomerase A6 antibody Thioredoxin domain containing 7 (protein disulfide isomerase) antibody Thioredoxin domain containing protein 7 antibody Thioredoxin domain-containing protein 7 antibody TXNDC7 antibody
Application: WB,IF-Cell,IF-Tissue,FC
Epitope Region: Recombinant protein within PDIA6 aa 1-108 / 440.
Protein Target: ER protein 5, ERp5, PDIA6
Target Species: Human,Mouse
Species Reactivity: Human,Mouse