E0616Hu
Human Aquaporin 4, AQP-4 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Forms a water-specific Channel (PubMed: 7559426, PubMed: 8601457, PubMed: 19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid Peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
DETAILS
- GeneID: 361
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 34,830
- Synonyms: AQP 4;AQP4;AQP-4;Aquaporin-4;Mercurial-insensitive water Channel;MIWC;WCH4
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: AQP4
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.022ng/ml
- Target Protein: AQP4
- Detection Range: 0.05-20ng/ml
- Full Product Name: Aquaporin 4
- Standard Solution: 24ng/ml
- UniProt Accession: P55087