FITC-Labeled Human EGFRvIII Protein, His Tag

DESCRIPTION

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumor-specific antigen is ligand-independent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CAR-modified T-cell studies in recent years.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 25ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: FITC-Labeled Human EGFRvIII Protein, His Tag (EGI-HF2H7) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 378 (Accession # NP_001333870.1). It is the FITC labeled form of Human EGFRvIII Protein, His Tag (EGI-H52H4).
Storage: -20℃, aviod light
Category: Fluorescent labeled protein
Molecule: EGFRvIII
Accession: NP_001333870.1
Conjugate: FITC Labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Leu 25 - Ser 378
Package Size: 25ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.5 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 40.5 kDa
Shipping Condition: RT
Species Reactivity: Human
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