DESCRIPTION

• Target: SUR1
• Gene Id: 25559
• Isotype: IgG1
• Conjugate: RPE
• Immunogen: Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
• References: 1. Campbell J.D., Sansom M.S., Ashcroft F.M. (2003) EMBO Resp. 4(11): 1038-1042. 2. Nichols C.G. (2006) Nature. 440 (7083): 470-476.
• Swiss-prot: Q09429
• Specificity: Detects ~160kDa. Does not cross-react with SUR2B.
• Applications: WB | IHC | ICC/IF
• Clone Number: N289/16 (Formerly sold as S289-16)
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Neuroscience | Cell Markers | Neuron Markers | Membrane Markers | Cell Signaling | Cancer | cardiovascular System | Atherosclerosis | Heart
• Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_037171.2
• Alternative Names: AM60008PU-N Antibody, ABC36 Antibody, Abcc8 Antibody, ATP binding cassette sub family C member 8 Antibody, HHF1 Antibody, HRINS Antibody, MRP8 Antibody, PHHI Antibody, SUR Antibody, SUR1 Antibody, Sulfonylurea receptor (hyperinsulinemia) Antibody, ATP binding cassette sub family C (CFTR/MRP) member 8 Antibody, ATP binding cassette transporter sub family C member 8 (1) Antibody, ATP-binding cassette sub-family C member 8 Antibody, HI Antibody, PHHI Antibody, Sulfonylurea receptor 1 Antibody, SUR1delta2 Antibody, TNDM2 Antibody
• Antibody Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-409D-RPE, RRID: AB_2701126
• Immunogen Species: Rat
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Membrane
• Scientific Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).
• Certificate of Analysis: 1 µg/ml of SMC-409 was sufficient for detection of SUR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat | Hamster