RGS19 Antibody (S151) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 10287
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RGS19
Other Names: Regulator of G-protein signaling 19, RGS19, G-alpha-interacting protein, GAIP, RGS19, GAIP, GNAI3IP
Availability: 2 weeks
Bio Background: RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).
Bio References: Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) Greenberg JT. Dev Cell. 8(6):799-801. (2005) Levine B. Cell. 120(2):159-62. (2005) Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004)de Vries L., et al. PNAS 93:15203-15208(1996) de Alba E., et al. J. Mol. Biol. 291:927-939(1999) Wang J., et al. J. Biol. Chem. 273:26014-26025(1998) Ogier-Denis E., et al. J. Biol. Chem. 275:39090-39095(2000)
Primary Accession: P49795
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1820f was selected from the S151 region of human RGS19. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.