680C91

DESCRIPTION

A TDO inhibitor (IC50s = 1.46 and 0.28 µM for the mouse and human enzymes, respectively); selective for TDO over IDO (IC50 = >80 µM for the mouse enzyme); inhibits dexamethasone-induced migration of SK-MEL-28 cells at 40 µM; increases brain levels of tryptophan, 5-HT, and 5-HIAA in rats

DETAILS

Inchi: InChI=1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Neuroscience
Smiles: FC1=CC=C2C(/C=C/C3=CN=CC=C3)=CNC2=C1
Inchikey: YBSDQTBCNYWBMX-ONEGZZNKSA-N
Cas Number: 163239-22-3
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C15H11FN2
Formula Weight: 238.3
Shelf Life Days: 1460