mouse monoclonal IgG1; PDE6β Antibody (B-8) is an IgG1 κ mouse monoclonal PDE6 beta antibody (also designated GMP-PDE beta antibody or PDE6B antibody) that detects the PDE6 beta protein of mouse, rat and human origin by WB, IP, IF and ELISA. PDE6β Antibody (B-8) is available as both the non-conjugated anti-PDE6 beta antibody form, as well as multiple conjugated forms of anti-PDE6 beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE6) plays a crucial role in the phototransduction cascade in the vertebrate retina. The enzyme consists of an α and a β subunit, with catalytic and cGMP binding activity, respectively, as well as two inhibitory γ subunits and a δ subunit. PDE6 reduces intracellular cytoplasmic cGMP levels, specifically in photoreceptor cells. Mutations in the human PDE6A gene, which encodes the α subunit, account for roughly 3-4% of the cases of recessive retinitis pigmentosa (RP) in North America.