mouse monoclonal IgG1; galectin-4 Antibody (E-2) is an IgG1 κ mouse monoclonal galectin-4 antibody that detects galectin-4 of mouse origin by WB, IP, IF, IHC(P) and ELISA. galectin-4 Antibody (E-2) is available as the non-conjugated anti-galectin-4 antibody form, as well as multiple conjugated forms of anti-galectin-4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. One member of this family, galectin-4, also known as Gal-4, L36 or LGALS4, maps to human chromosome 19q13.2. The galectin-4 protein is composed of 323 amino acids and contains two homologous carbohydrate recognition domains (CRD) and all amino acids typically conserved in the galectin family. Expression of galectin-4 correlates with the malignant potential of human hepatocellular carcinoma (HCC) and is differentially regulated depending on cell-cell contact, serum growth factors, cell growth and cell differentiation status. Galectin-4 expression is detected in epithelial cells of the colon, rectum and intestine, and in HT29 and LS174T cell lines. Galectin-4 is underexpressed in colorectal cancer and is preferentially upregulated in cells prone to peritoneal dissemination.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.