Anti-CD81 Monoclonal Antibody (Clone:M38)-Low Endotoxin

DESCRIPTION

CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.

DETAILS

Gene: CD81
App Id: FACS
Antigen: CD81
Gene Id: 975
Isotype: Mouse IgG1
Format Id: Low Endotoxin
Clone Name: M38
Uniprot Id: P60033
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Purified by protein-A affinity chromatography
Reactivity Id: Human
Alternative Name: CD81||TAPA1||TSPAN28
Application Note: Functional application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines. Flow cytometry: recommended dilution: 1µg/ml. Western blotting: recommended dilution: 1-2µg/ml; positive control: Jurkat cells, non-reducing conditions.
Storage Condition: Store at 2-8°C. Do not freeze.
Immunogen Information: MOLT-4 (human T-ALL cell line)