DESCRIPTION

• Mw: 2728.2 Da
• Format: Aqueous buffer solution
• Purity: ≥95%
• Shiptemp: -20°C
• Synonyms: Bromodomain, bromodomain ligand, BET ligand
• Warnings: Avoid freeze/thaw cycles.
• Category: Bromodomain/Ligands
• Background: Bromodomains function as acetyl-lysine binding domains, and bromodomain/ acetyl-lysine recognition can regulate histone modification, DNA replications, chromatin remodeling, and gene transcription.
• References: 1. Jasencakova, Z. et al. Plant Cell 12, 2087 (2000).2. Johnson, C. et al. Nucl Acids Res 26, 994 (1998).
• Description: The BET Bromodomain Ligand is peptide histone H4 (1-21), acetylated at lysine 5, 8, 12 and 16. It contains a C-terminal GG linker, followed by a biotinylated Lys. This peptide is suitable for use as a ligand for several bromodomains including members of the BET bromodomain family: BRD2, BRD3, BRD4, and BRDT. It also binds to several other bromodomains which are not included in the BET bromodomain family.
• Supplied As: 20 µM aqueous solution
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. It is a component of several BPS Bioscience BRD Assay Kits.
• Product Type: Substrate
• Concentration: 20 µM
• Biosafety Level: Not applicable (BSL-1)
• Storage Stability: At least 6 months from date of receipt, when stored as directed
• Amino Acid Sequence: SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K(Biotin)
• Scientific Category: Bromodomain