IWP-3

DESCRIPTION

IWP-3 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.

DETAILS

Purity: ≥98%
Synonyms: Inhibitor of Wnt Production-3
Cas Number: 687561-60-0
References: Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Willems, E., Spiering, S., Davidovics, H., Lanier, M., Xia, Z., Dawson, M., ... & Mercola, M. (2011). Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell–derived mesoderm.Circulation research, 109(4), 360-364. Lanier, M., Schade, D., Willems, E., Tsuda, M., Spiering, S., Kalisiak, J., ... & Cashman, J. R. (2012). Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure–activity relationship study based on inhibitors for the Wnt response. Journal of medicinal chemistry, 55(2), 697-708.
Application: FA
Formulation: Crystalline solid
Chemical Name: 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N- (6-methyl-2-benzothiazolyl)-acetamide
Molecular Weight: 484.6
Molecular Formula: C22H17FN4O2S3
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=C(C=C5)F)SCC4