FGFR2, Avi-His-Tag Recombinant

DESCRIPTION

Human recombinant FGFR2 (Fibroblast growth factor receptor 2, also known as CD332), corresponding to amino acids 22-377, the extracellular domain. This construct contains a C-terminal Avi-Tag™ followed by a His-Tag (6xHis). The recombinant protein was affinity purified.

DETAILS

Aa: 22-377
Mw: 43 kDa + glycans
Tags: C-terminal Avi-Tag™, His-Tag
Format: Aqueous buffer solution.
Purity: ≥90%
Genbank: NM_000141.5
Species: Human
Uniprot: P21802
Shiptemp: -80°C (dry ice)
Synonyms: Fibroblast growth factor receptor 2, K-sam (KGFR), Keratinocyte growth factor receptor, CD332, BEK, KGFR, KSAM
Warnings: Avoid freeze/thaw cycles
Category: Immunotherapy/Protein
Background: Fibroblast Growth Factor Receptor 2 (FGFR2) belongs to a family of transmembrane receptors with tyrosine kinase activity playing a key role in cell growth, differentiation, and tissue repair. Receptor activation by FGF ligands triggers signaling pathways that ultimately regulate cell proliferation and differentiation. FGFR2 is essential for embryonic development, particularly in the formation of the skeletal system and the development of the central nervous system. It also plays a significant role in wound healing, tissue regeneration, and tissue maintenance in adults. Dysfunction of FGFR2 is associated with a range of disorders, including craniosynostosis and certain types of cancer, therefore, FGFR2 is a candidate therapeutic target in conditions where its function is dysregulated.
Constructs: FGFR2 (22-377-Avi-His)
Description: Human recombinant FGFR2 (Fibroblast growth factor receptor 2, also known as CD332), corresponding to amino acids 22-377, the extracellular domain. This construct contains a C-terminal Avi-Tag™ followed by a His-Tag (6xHis). The recombinant protein was affinity purified.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Unspsc Code: 12352202
Unspsc Name: Proteins
Host Species: HEK293
Product Type: Protein
Biosafety Level: Not applicable (BSL-1)
Related Products: 40211, 79804, 100350
Storage Stability: At least 6 months at -80°C.
Scientific Category: Cell Signaling Pathway
Instructions for Use: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.
Signed License Required: No