400-03
Recombinant Rat IL-3beta
PeproTech
DESCRIPTION
IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Rat IL-3beta is a 16.3 kDa globular protein containing 144 amino acid residues.
DETAILS
- Gene Id: 24495
- Uniprot: P97688
- Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is ≤ 10 ng/ml, corresponding to a specific activity of ≥1.0 x 10^5 units/mg.
- Category: RUO Cytokines
- Subcategory: Growth Factors & Cytokines
- Research Areas: AIDS/HIV, Cancer, Cell Culture, Diabetes/Weight Regulation, Immune System, Stem Cells and Differentiation
- Alternative Names: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor
- Species of Origin: Rat
- Expression System Source: E.coli