10-3004-P
Monoclonal Antibody to TLR3 (Clone: ABM15D5)-PE conjugated
Abeomics
DESCRIPTION
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
DETAILS
- Gene: TLR3
- App Id: FACS
- Antigen: TLR3
- Gene Id: 7098
- Isotype: Mouse IgG1 Kappa
- Format Id: Purified
- Clone Name: ABM15D5
- Uniprot Id: O15455
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Purification: Protein G Chromatography
- Reactivity Id: Human
- Product Content: 0.04mg/ml in PBS with 0.05% Azide.
- Alternative Name: TLR3
- Application Note: FACS analysis: 0.5-1 µg/10^6 cells
- Storage Condition: Store the antibody at 4°C, stable for 6 months.
- Immunogen Information: A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
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