BMS 195614

DESCRIPTION

A neutral RARα-selective antagonist (Ki = 2.5 nM); antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding

DETAILS

Inchi: InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34)
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Epigenetics, Transcription, & Translation
Smiles: CC1(C)C2=CC=C(C(NC3=CC=C(C(O)=O)C=C3)=O)C=C2C(C4=CC(C=CC=C5)=C5N=C4)=CC1
Inchikey: WGLMBRZXZDAQHP-UHFFFAOYSA-N
Cas Number: 182135-66-6
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C29H24N2O3
Formula Weight: 448.5
Shelf Life Days: 1460