mouse monoclonal IgG2b; NOD9 Antibody (F-2) is an IgG2b κ mouse monoclonal NOD9 antibody (also designated NLRX1 antibody) that detects the NOD9 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. NOD9 Antibody (F-2) is available as both the non-conjugated anti-NOD9 antibody form, as well as multiple conjugated forms of anti-NOD9 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The leucine-rich repeat (LRR) is a 20-30 amino acid motif that forms a hydrophobic α/β horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRRs contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. NOD9, also known as NLRX1, NOD26 or NOD5, is a 975 amino acid outer mitochondrial membrane protein that contains one NACHT domain and four LRRs. Expressed at high levels in heart, muscle and mammary gland, NOD9 plays a role in antiviral signaling, specifically via inhibition of virus-induced helicases, thereby acting as a negative regulator of antiviral responses. Two isoforms of NOD9 exist due to alternative splicing events.