• Aa: 27-684(end)
• Mw: 76 kDa
• Tags: N-terminal FLAG-tag
• Format: Aqueous buffer solution
• Genbank: NM_006515
• Species: Human
• Uniprot: Q53H47
• Shiptemp: -80°C (dry ice)
• Synonyms: Setmar, Metnase
• Warnings: Avoid freeze/thaw cycles.
• Category: Methyltransferase/Enzymes
• Background: SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends. SETMAR has histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair. Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element.
• References: 1. Wray J. et al., Blood 114(9), 1852-1858 (2009). 2. Williamson E.A. et al., Nucleic Acids Res. 36 (18), 5822-5831 (2008).
• Description: Human Metnase (SETMAR, or SET domain and mariner transposase fusion), GenBank Accession No. NM_006515, a.a. 27-684(end), with N-terminal FLAG-tag, MW=76 kDa, expressed in FreeStyle 293-F cells.
• Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 90 ?g/ml FLAG peptide, and 10% glyceroll
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 
• Host Species: human
• Product Type: Protein
• Host Cell Line: Freestyle 293-F cells
• Biosafety Level: Not applicable (BSL-1)
• Storage Stability: At least 6 months at -80°C.
• Scientific Category: Methyltransferase

DESCRIPTION