T36207
Methylspinazarin
TargetMol
DETAILS
- Purity: 98%
- Smiles: Cc1cc(O)c2C(=O)C(O)=C(O)C(=O)c2c1O |t:9|
- Category: Compounds
- Cas Number: 41768-12-1
- Molecular Weight: 236.179
- Molecular Formula: C11H8O6
DESCRIPTION
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg.
Lead Time: 4 - 5 weeks
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