MeCP2 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 4204
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MECP2
Other Names: Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Availability: 2 weeks
Bio Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Bio References: dos Santos, J.M., et al., Neurosci. Lett. 379(1):13-16 (2005).Ylisaukko-Oja, T., et al., Am J Med Genet A 132(2):121-124 (2005).Schanen, C., et al., Am J Med Genet A 126(2):129-140 (2004).Shibayama, A., et al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 128(1):50-53 (2004).Fang, J.Y., et al., World J. Gastroenterol. 10(23):3394-3398 (2004).
Primary Accession: P51608
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2545a was selected from the N-term region of human MeCP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.