HA720100
Scientist.com Supplier
Anti-NCAPD2 Antibody [JE62-22]
HuaBio
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DESCRIPTION
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
DETAILS
- Host: Rabbit
- Type: Primary
- Uniprot: SwissProt: Q15021 Human
- Clone Id: JE62-22
- Clonality: Recombinant Rabbit monoclonal Antibody
- Conjugate: Non-conjugated
- Alias Names: 2810406C15Rik antibody 2810465G24Rik antibody CAP-D2 antibody CAPD2 antibody CEP2 antibody CEP250 antibody Chromosome condensation-related SMC-associated protein 1 antibody Chromosome-associated protein D2 antibody CNAP1 antibody CND1 antibody Condensin antibody Condensin complex subunit 1 antibody eg7 antibody hCAP-D2 antibody hCAPD2 antibody KIAA0159 antibody mKIAA0159 antibody NCAPD2 antibody non-SMC condensin I complex, subunit D2 antibody XCAP D2 homolog antibody
- Application: WB,IF-Cell,IHC-P
- Epitope Region: Recombinant protein within human NCAPD2 aa 51-200/1,401.
- Protein Target: NCAPD2
- Target Species: Human
- Species Reactivity: Human