SMC-600D-BI
Scientist.com Supplier
Alpha Synuclein Antibody (pSer129), Clone J18: Biotin
Stressmarq Biosciences
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DESCRIPTION
Rabbit Anti-Human Alpha Synuclein pSer129 Monoclonal IgG
DETAILS
- Target: Alpha Synuclein (pSer129)
- Gene Id: 6622
- Isotype: IgG
- Conjugate: Biotin
- Immunogen: Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys
- References: 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Fujiwara H., et al. (2002) Nat Cell Biol. 4(2):160-4. 8. Anderson J.P., et al. (2006) J Biol Chem. 281(40):29739-52.
- Swiss-prot: P37840
- Specificity: Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein
- Applications: ELISA | WB | ICC | IHC
- Clone Number: J18
- Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Host Species: Rabbit
- Product Type: Monoclonal
- Purification: Affinity Purified
- Concentration: 1 mg/ml
- Research Areas: Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Neuroscience | Neurodegeneration | Multiple System Atrophy
- Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
- Accession Number: NP_000336.1
- Alternative Names: Phosphorylated alpha synuclein antibody, Phospho anti-alpha Synuclein (S129) antibody, Alpha-synuclein (phospho S129) antibody, alpha Synuclein (phospho Ser129) antibody, alpha-Synuclein Phospho Ser129 Antibody, phospho-α-Synuclein (Ser129) Antibody, Alpha synuclein antibody, Alpha synuclein antibody phospho Serine 129, Alpha synuclein antibody phospho Ser 129, Alpha synuclein antibody pSerine 129, Alpha synuclein antibody pSer 129, Alpha synuclein antibody phosphoSer 129, Alpha-synuclein antibody, Alpha-synuclein, isoform NACP140 antibody, alphaSYN antibody, NACP antibody, Non A beta component of AD amyloid antibody, Non A4 component of amyloid antibody, Non A4 component of amyloid precursor antibody, Non-A beta component of AD amyloid antibody, Non-A-beta component of alzheimers disease amyloid , precursor of antibody, Non-A4 component of amyloid precursor antibody, Non-A4 component of amyloid, precursor of antibody, PARK 1 antibody, PARK 4 antibody, PARK1 antibody, PARK4 antibody, Parkinson disease (autosomal dominant, Lewy body) 4 antibody, Parkinson disease familial 1 antibody, SNCA antibody, alpha (non A4 component of amyloid precursor) antibody, SYN antibody, Synuclein alpha antibody, Synuclein alpha 140 antibody, Synuclein, alpha (non A4 component of amyloid precursor) antibody, SYUA_HUMAN antibody
- Antibody Dilution: WB (1:500); optimal dilutions for assays should be determined by the user.
- Cite This Product: Rabbit Anti-Human Alpha Synuclein pSer129 Monoclonal (StressMarq Biosciences, Victoria BC, Cat# SMC-600D-BI)
- Immunogen Species: Human
- Tissue Specificity: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
- Storage Temperature: Conjugated antibodies should be stored according to the product label
- Shipping Temperature: Blue Ice or 4ºC
- Cellular Localization: Cytoplasm | Cytosol | Membrane | Nucleus | Cell Junction | Synapse
- Scientific Background: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90% of the alpha synuclein found in Lewy bodies (7, 8).
- Certificate of Analysis: A 1:500 dilution of SMC-600 was sufficient for detection of Alpha Synuclein pSer129 in 10 µg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
- Species Reactivity Full Name: Human | Mouse