8260480-250mg 8260480-50mg
Raloxifene hydrochloride
Biogems
DESCRIPTION
Raloxifene is a selective estrogen receptor modulator that tissue-dependently either activates or blocks estrogen-induced transcription. It acts as an estrogen agonist in bone tissue and as an antiestrogen in breast or uterine tissue. Raloxifene is reported to enhance osteoblast differentiation and protects endothelial cells against oxidative stress.
DETAILS
- Purity: ≥98%
- Synonyms: Evista, Keoxifene, LY 156758, LY156758
- Cas Number: 82640-04-8
- References: Delmas, P. D., Bjarnason, N. H., Mitlak, B. H., Ravoux, A. C., Shah, A. S., Huster, W. J., ... & Christiansen, C. (1997). Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. New England Journal of Medicine, 337(23), 1641-1647. Black, L. J., Sato, M., Rowley, E. R., Magee, D. E., Bekele, A., Williams, D. C., ... & Bensch, W. R. (1994). Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. Journal of Clinical Investigation, 93(1), 63. Taranta, A., Brama, M., Teti, A., Scandurra, R., Spera, G., Agnusdei, D., ... & Migliaccio, S. (2002). The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro. Bone, 30(2), 368-376.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;hydrochloride
- Molecular Weight: 510.2
- Molecular Formula: C28H27NO4S HCl
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl