SB 204990

DESCRIPTION

A cell-permeable prodrug of SB 201076; inhibits fatty acid and cholesterol synthesis in HepG2 cells in a concentration-dependent manner; reduces plasma levels of the lipoproteins VLDL, LDL, and HDL by 21, 40, and 22%, respectively, in dogs when administered orally at a dose of 25 mg/kg; reduces VLDL synthesis and plasma cholesterol and triglyceride levels in rats in a dose-dependent manner

DETAILS

Inchi: InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
Smiles: O=C1[C@](CC(O)=O)(O)C[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)O1
Inchikey: YTRNLFYTHYWDAU-KDOFPFPSSA-N
Cas Number: 154566-12-8
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C18H22Cl2O5
Formula Weight: 389.3
Shelf Life Days: 1460