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SB 525334
Biogems
DESCRIPTION
SB 525334 is a selective and potent inhibitor of the TGF-Beta receptor 1 (ALK5). It exhibits no inhibition of ALK2, ALK3, and ALK6. It blocks the activation of Smad2/3 by TGF-β1 in renal proximal tubule cells and attenuates bleomycin-induced pulmonary fibrosis.
DETAILS
- Purity: ≥98%
- Synonyms: SB-525334, 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
- Cas Number: 356559-20-1
- References: Higashiyama, H., Yoshimoto, D., Kaise, T., Matsubara, S., Fujiwara, M., Kikkawa, H., ... & Kinoshita, M. (2007). Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. Experimental and molecular pathology, 83(1), 39-46. Grygielko, E. T., Martin, W. M., Thornton, P., Tweed, C., & Laping, N. J. (2002, September). SB-525334, a novel TGF-beta type I receptor kinase inhibitor in the puromycin aminonucleoside model of renal disease. InJOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (Vol. 13, pp. 5A-5A). 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA: LIPPINCOTT WILLIAMS & WILKINS. Underwood, D. C., Osborn, R. R., Grygielko, E. T., & Laping, N. J. (2003). SB-525334, a novel TGF-beta type 1 receptor kinase inhibitor, prevents ans reverses Bleopmycin-induced pulmonary fibrosis in the rat.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline
- Molecular Weight: 343.4
- Molecular Formula: C21H21N5
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3