K-41 | Scientist.com

DESCRIPTION

A fungal metabolite with antibiotic and antiparasitic activities; active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively); active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively); has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively)

DETAILS

Inchi: InChI=1S/C48H82O18/c1-23-38(62-37-20-18-30(54-10)28(6)59-37)25(3)46(9,52)65-39(23)33-16-15-31(60-33)32-17-19-35(61-32)45(8)42(57-13)27(5)48(66-45)24(2)34(55-11)21-29(63-48)22-36-44(7,58-14)41(56-12)26(4)47(53,64-36)40(49)43(50)51/h23-42,49,52-53H,15-22H2,1-14H3,(H,50,51)/t23-,24+,25+,26-,27+,28+,29-,30-,31+,32-,33+,34+,35+,36-,37-,38-,39-,40-,41-,42+,44-,45+,46-,47-,48-/m0/s1
Purity: ≥70%
Raptas: Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Infectious Disease|Parasitic Diseases|Malaria
Smiles: CO[C@@H]1C[C@](C[C@H]2[C@@](OC)(C)[C@@H](OC)[C@H](C)[C@]([C@H](C(O)=O)O)(O)O2)([H])O[C@]3(O[C@@]([C@@]4([H])CC[C@]([C@]5([H])O[C@]([C@]6([H])[C@@H](C)[C@H](O[C@@H]7O[C@H](C)[C@@H](OC)CC7)[C@@H](C)[C@](O)(C)O6)([H])CC5)([H])O4)(C)[C@H](OC)[C@H]3C)[C@@H]1C
Inchikey: QFHLVPYVNFSTBE-SMAIMEEGSA-N
Cas Number: 53026-37-2
Formulation: A solid
Item Origin: Bacterium/Streptomyces sp.
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C48H82O18
Formula Weight: 947.2
Shelf Life Days: 1460