21981
YMU1
Cayman Chemical
DESCRIPTION
A thymidylate kinase inhibitor (IC50 = 610 nM); selective for thymidylate kinase over thymidine kinase 1; reduces dTTP levels by 30-40% in p58-/- HCT116 cells; sensitizes a variety of cancer cell lines to doxorubicin; reduces tumor growth in a p53-/- HCT116 mouse xenograft model at 5 mg/kg three times per week for four weeks
DETAILS
- Inchi: InChI=1S/C17H22N4O4S/c1-4-25-17(24)20-7-5-19(6-8-20)13(22)10-21-16(23)14-11(2)9-12(3)18-15(14)26-21/h9H,4-8,10H2,1-3H3
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Metabolism||Research Area|Cancer|Transcription Factors|p53
- Smiles: O=C(OCC)N1CCN(C(CN(SC2=C3C(C)=CC(C)=N2)C3=O)=O)CC1
- Inchikey: XXUFNNVFZFVKGP-UHFFFAOYSA-N
- Cas Number: 902589-96-2
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C17H22N4O4S
- Formula Weight: 378.5
- Shelf Life Days: 1460
Equivalent Items
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