3058716-1g 3058716-100mg
Zidovudine
Biogems
DESCRIPTION
Zidovudine (Azidothymidine or AZT) is a thymidine analogue that selectively inhibits HIV’s reverse transcriptase. It is reported to be inhibit DNA polymerase used by human cells in high doses. Zidovudine can also be used to decrease CRISPR-mediated homology-directed repair efficiency.
DETAILS
- Purity: ≥98%
- Synonyms: Azidothymidine, AZT, 3' Azido 2',3' Dideoxythymidine, Retrovir, Zidovudinum
- Cas Number: 30516-87-1
- References: Blum, M. R., Liao, S. H., Good, S. S., & De Miranda, P. (1988). Pharmacokinetics and bioavailability of zidovudine in humans. The American journal of medicine, 85(2A), 189-194. Yu, C., Liu, Y., Ma, T., Liu, K., Xu, S., Zhang, Y., ... & Qi, L. S. (2015). Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell stem cell, 16(2), 142-147. de la Fuente-Núñez, C., & Lu, T. K. (2017). CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects. Integrative Biology. Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., ... & Jackson, G. G. (1987). The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. New England Journal of Medicine, 317(4), 185-191.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- Molecular Weight: 267.3
- Molecular Formula: C10H13N5O4
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]