mouse monoclonal IgG2b; Chx10 Antibody (D-11) is an IgG2b κ mouse monoclonal Chx10 antibody that detects Chx10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Chx10 Antibody (D-11) is available as the non-conjugated anti-Chx10 antibody form, as well as multiple conjugated forms of anti-Chx10 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Chx10, for ceh-10 homeodomain containing homolog, is also known as RET1 and HOX10 and is closely related to the homeodomain of the homeobox gene ceh-10 from the nematode Caenorhabditis elegans. Chx10 is an essential component in the network of genes required for the development of the mammalian eye, with profound effects on retinal progenitor proliferation and bipolar cell specification or differentiation. Chx10 is expressed in the early retinal neuroepithelium, is restricted to bipolar cells and is maintained at a low level in bipolar cells of the mature retina. Human CHX10 is also expressed in the inner nuclear layer of the mature retina. Expression patterns implicate critical roles in the formation of the neuroretina and in the development and maintenance of the inner nuclear layer. Chx10 is expressed at high levels in uncommitted retinal progenitor cells and mature bipolar cells.