T5339
YZ129
TargetMol
DESCRIPTION
YZ129, a glioblastoma inhibitor, targets the HSP90-calcineurin-NFAT pathway by directly binding to heat shock protein 90 (HSP90) and exhibits an IC 50 of 820 nM on NFAT nuclear translocation. It induces cell-cycle arrest at the G2/M phase in GBM cells, leading to apoptosis and inhibiting tumor cell proliferation and migration [1].
DETAILS
- Cas: 1643120-60-8
- Purity: 98%
- Smiles: N(C=1C=2C(C(=O)C(=O)C1)=CC=CC2)C3=CC4=C(C=C3)C=NC=C4
- Category: Compound
- Molecular Weight: 300.31
- Molecular Formula: C19H12N2O2
Lead Time: 4 - 5 weeks
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