Nuclear-encoded Humanin Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MT-RNR2
Other Names: Humanin, Humanin mitochondrial, HNM, MT-RNR2 (HGNC:7471)
Availability: 2 weeks
Bio Background: Humanin is a secreted protein that serves as a neuroprotective factor against death induced by an array of Alzheimer's related proteins, including beta amyloid. Humanin diminishes aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and competitively inhibits the access of FPRL1 to APP. This protein has also been demonstrated to block the translocation of BAX from cytosol to mitochondria. Expression of humanin is abundant in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Humanin is well-expressed in brain tissue afflicted with Alzheimer's, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus. Intracellular levels of human are regulated by TRIM11 through the proteasomal pathway.
Bio References: Proc. Natl. Acad. Sci. U.S.A. 98 (11), 6336-6341 (2001)Neurosci. Lett. 324 (3), 227-231 (2002)Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003).J. Neurosci. 21:9235-9245(2001).Nature 423:456-461(2003).Eur. J. Neurosci. 17:1150-1158(2003).J. Immunol. 172:7078-7085(2004).
Primary Accession: Q8IVG9
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1324a was selected from the region of human Nuclear-encloded Humanin. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.