mouse monoclonal IgG2b; PGAM1/4 Antibody (D-5) is an IgG2b κ mouse monoclonal PGAM1/4 antibody (also designated PGAM1/4 antibody) that detects the PGAM1/4 protein of mouse, rat and human origin by WB, IP, IF and ELISA. PGAM1/4 Antibody (D-5) is available as both the non-conjugated anti-PGAM1/4 antibody form, as well as multiple conjugated forms of anti-PGAM1/4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the PGAM (phosphoglycerate mutase) family of proteins are important components of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism. They are responsible for catalyzing the transfer of phospho groups between the carbon atoms of phosphoglycerates. In mammals there are two types of PGAM isozymes: PGAM1 (also known as PGAMB) and PGAM2 (also known as PGAMA). In the cell, PGAM1 and PGAM2 exist as either homodimers or heterodimers and are responsible for the interconversion of 3-phosphoglycerate and 2-phosphoglycerate. PGAM2 homodimers are expressed in skeletal muscle, mature sperm cells and heart; PGAM1 homodimers are found in most other tissues; and PGAM1/PGAM2 heterodimers are found exclusively in the heart. PGAM4, also known as PGAM3, is a protein formerly considered to be specific to humans. Initially the PGAM4 gene was described as a pseudogene but it is now known to encode a functional protein at least 25 million years old. The gene encoding PGAM4 is believed to have originated by retrotransposition, with the original copy being the PGAM1 gene.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.