11,12-EET

DESCRIPTION

11,12-EET is a cytochrome P450-derived molecule that is reported to inhibit the epithelial sodium channel (ENaC). It is also reported to be involved in the recovery of Ca2+ pool-depleted cells as sustained increases in EETs may amplify Ca2+ signaling.

DETAILS

Purity: ≥95%
Synonyms: 11,12-epoxyeicosatrienoic acid; 11,12-Eet; 11,12-epoxy-5,8,14-eicosatrienoic acid; 11,12-Oxido-5,8,14-eicosatrienoic acid; 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
Cas Number: 123931-40-8
References: Falck, J. R., Reddy, L. M., Reddy, Y. K., Bondlela, M., Krishna, U. M., Ji, Y., ... & Liao, J. K. (2003). 11, 12-Epoxyeicosatrienoic acid (11, 12-EET): structural determinants for inhibition of TNF-α-induced VCAM-1 expression.Bioorganic & medicinal chemistry letters, 13(22), 4011-4014. Potente, M., Fisslthaler, B., Busse, R., & Fleming, I. (2003). 11, 12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. Journal of Biological Chemistry, 278(32), 29619-29625. Li, P. L., Chen, C. L., Bortell, R., & Campbell, W. B. (1999). 11, 12-Epoxyeicosatrienoic acid stimulates endogenous mono-ADP-ribosylation in bovine coronary arterial smooth muscle. Circulation Research, 85(4), 349-356.
Application: FA
Formulation: Ethanol Solution
Chemical Name: (5E,8E)-10-[3-[(E)-oct-2-enyl]oxiran-2-yl]deca-5,8-dienoic acid
Molecular Weight: 320.5
Molecular Formula: C20H32O3
Storage Conditions: Product should be kept at-20°C.
Pubchem Openeye Can Smiles: CCCCCC=CCC1C(O1)CC=CCC=CCCCC(=O)O