8946314-50mg 8946314-10mg
DMOG
Biogems
DESCRIPTION
DMOG is a cell permeable Prolyl 4-hydroxylase (P4H) inhibitor which activates the hypoxia-inducible factor (HIF) in cultured cells. DMOG is reported to delay neuronal cell death caused by trophic factor deprivation through a HIF-1 alpha-independent, glucose-dependent mechanism.
DETAILS
- Purity: ≥98%
- Synonyms: Dimethyloxallyl glycine, dimethyloxalylglycine, methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
- Cas Number: 89464-63-1
- References: Hill, P., Shukla, D., Tran, M. G., Aragones, J., Cook, H. T., Carmeliet, P., & Maxwell, P. H. (2008). Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. Journal of the American Society of Nephrology, 19(1), 39-46. Milkiewicz, M., Pugh, C. W., & Egginton, S. (2004). Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.The Journal of physiology, 560(1), 21-26. Sears, J. E., Hoppe, G., Ebrahem, Q., & Anand-Apte, B. (2008). Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.Proceedings of the National Academy of Sciences, 105(50), 19898-19903.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetat
- Molecular Weight: 175.1
- Molecular Formula: C6H9NO5
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: COC(=O)CNC(=O)C(=O)OC