1422097-10mg 1422097-1mg
Kenpaullone
Biogems
DESCRIPTION
Kenpaullone is a potent ATP-competitive inhibitor of glycogen synthase kinase 3Beta and CDK1/Cyclin B. It also inhibits CDk2/Cyclin A, CDk5/p25, and CDk2/Cyclin E. Kenpaullone is reported to enhance the chemical reprogramming of induced pluripotent stem cells from somatic cells.
DETAILS
- Purity: ≥98%
- Synonyms: 1-azakenpaullone, NSC-664704
- Cas Number: 142273-20-9
- References: Brault, L., Migianu, E., Néguesque, A., Battaglia, E., Bagrel, D., & Kirsch, G. (2005). New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells. European journal of medicinal chemistry,40(8), 757-763. Phiel, C. J., Wilson, C. A., Lee, V. M. Y., & Klein, P. S. (2003). GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature,423(6938), 435-439. Schultz, C., Link, A., Leost, M., Zaharevitz, D. W., Gussio, R., Sausville, E. A., ... & Kunick, C. (1999). Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. Journal of medicinal chemistry, 42(15), 2909-2919.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
- Molecular Weight: 327.2
- Molecular Formula: C16H11BrN2O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br