E1989Hu
Human Bone Morphogenetic Protein 2, BMP-2 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Induces cartilage and bone formation (PubMed: 3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed: 24362451).
DETAILS
- Gene Id: 650
- Uniprot: P12643
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.01ng/ml
- Detection Range: 0.05-15ng/ml
- Detection Method: ELISA
- Species Reactivity: Human