mouse monoclonal IgG3; Mi2-β Antibody (F-7) is an IgG3 κ mouse monoclonal Mi2-beta antibody (also designated Mi2-β antibody) that detects the Mi2-beta protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Mi2-β Antibody (F-7) is available as the non-conjugated anti-Mi2-beta antibody. In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Chromatin structure alteration may be brought about by the action of ATP-dependent multiprotein complexes. One such complex is the mSin3 corepressor complex, which contains mSin3, the histone deacetylases HDAC1 and HDAC2, the associated proteins SAP 30 and SAP 18, and the autoantigens Mi2-α and Mi2-β.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.