36-2200-20 36-2200
Anti-EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody(Clone: B1D8)
Abeomics
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DESCRIPTION
This antibody reacts with the extracellular domain of EGFR and blocks the EGF/TGF'induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.
DETAILS
- Gene: EGFR
- App Id: IP,FACS
- Gene Id: 1956
- Isotype: Mouse IgG2a, kappa
- Clone Name: B1D8
- Uniprot Id: P00533
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Reactivity Id: Human
- Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Alternative Name: Erbb1; ERBB1; Errp; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor Tyrosine Protein Kinase; ErbB1; Urogastrone; wa2; Wa5
- Application Note: Affinity Purification (For coupling, order Ab without BSA); Blocks Ligand-induced Activation of EGFR; Inhibits Proliferation of A431 cells (Order Ab without sodium azide); Arrests Tumor Growth in vivo (Order Ab without BSA &Azide); Immunoprecipitation (1-2ug/500ug protein lysate); Flow Cytometry (1-2ug/million cells);
- Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
- Immunogen Information: Microsomes from A431 cells.