S2N-C52Hc-100ug S2N-C52Hc-1mg
SARS-CoV-2 S2 protein (A701V), His Tag
ACROBiosystems
Image
![](https://www.acrobiosystems.com/static/main/products/images/sds/S2N-C52Hc.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/S2N-C52Hc-E1.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/S2N-C52Hc-E2.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/S2N-C52Hc-E1.jpg)
DESCRIPTION
It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
DETAILS
- Tag: C-10×His
- Host: HEK293
- Size: 100ug
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 95%
- Source: SARS-CoV-2 S2 protein (A701V), His Tag (S2N-C52Hc) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P/ A892P/ A899P/ A942P/ K986P/ V987P) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein. The A701V mutation was identified in the SARS-CoV-2 Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2).
- Storage: -20℃
- Category: Viral Proteins
- Molecule: Spike S2
- Accession: QHD43416.1
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Ser 686 - Pro 1213
- Package Size: 100ug*1
- Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.8 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 59.8 kDa
- Shipping Condition: RT
- Species Reactivity: SARS-CoV-2
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html