E6171Hu
Human Short Branched Chain Specific Acyl-CoA Dehydrogenase, ACADSB ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:7698750, PubMed:11013134, PubMed:21430231, PubMed:10832746).
Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (PubMed:7698750, PubMed:11013134, PubMed:21430231, PubMed:10832746).
Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (PubMed:11013134, PubMed:10832746).
Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691).
DETAILS
- GeneID: 36
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 47,485
- Synonyms: 2-MEBCAD;2-methyl branched chain acyl-CoA dehydrogenase;2-methylbutyryl-CoA dehydrogenase;2-methylbutyryl-coenzyme A dehydrogenase;ACAD7;ACADSB;SBCAD;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: ACADSB
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 9.63ng/L
- Target Protein: ACADSB
- Detection Range: 20-4500ng/L
- Full Product Name: Short/branched chain specific acyl-CoA dehydrogenase
- Standard Solution: 4800ng/L
- UniProt Accession: P45954