mouse monoclonal IgG1; saposin C Antibody (A-3) is an IgG1 κ mouse monoclonal saposin C antibody (also designated sphingolipid activator protein-1 antibody, SAP1 antibody, sphingolipid activator protein-2 antibody, SAP2 antibody, variant Gaucher disease and variant metachromatic leukodystrophy antibody, prosaposin antibody, PSAP antibody, or Cerebroside sulfate activator antibody) that detects the saposin C protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. saposin C Antibody (A-3) is available as both the non-conjugated anti-saposin C antibody form, as well as multiple conjugated forms of anti-saposin C antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The saposin family includes four structurally related activator proteins, saposin A, B, C and D, that are cleaved from the single precursor protein prosaposin. The gene encoding human prosaposin maps to chromosome 10. Prosaposin is synthesized as a protein that is posttranslationally modified to a shorter form and then further glycosylated to yield a secretory product. This form subsequently undergoes partial proteolysis to produce saposin A, B, C and D. Each saposin family member acts in conjunction with hydrolase enzymes to facilitate the breakdown of glycosphingolipids within the lysosome. The saposins modify the environment of target lipids to make them accessible to the active sites of specific enzymes. Saposin A and C are involved in the hydrolysis of glucosylceramidase, and defects in saposin C are linked to Gaucher's disease. Saposin B facilitates the hydrolysis of the sulfate group from cerebroside sulfate, and defects in this protein are responsible for a form of metachromatic leukodystropy, a progressive neurodegenerative condition. Saposin D may stimulate the hydrolysis of sphingomyelin and ceramide, but its exact physiological role is not clear.