30-1361-0.1
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Anti-PKAc Monoclonal Antibody (Clone:6D2.1)
Abeomics
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DESCRIPTION
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.
DETAILS
- App Id: WB
- Antigen: PKAc
- Isotype: Mouse IgG1
- Format Id: Purified
- Clone Name: 6D2.1
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Purified by protein-A affinity chromatography
- Reactivity Id: Human
- Application Note: Western Blotting Recommended dilution: 0.5-1 µg/ml Positive control: HeLa human cervix carcinoma cell line
- Categories Name 1: Antibodies
- Categories Name 2: Cell Signalling
- Storage Condition: Store at 2-8°C. Do not freeze.
- Immunogen Information: Peptide corresponding to amino acids ESPAQNTAHLDQFERIK of human proteinkinase A c alpha (PKAc alpha).