Lipid AX4

DESCRIPTION

An ionizable cationic lipid (pKa = 6.89); has been used in the formation of LNPs for the delivery of mRNA in vivo; administration of LNPs containing lipid AX4 and encapsulating SARS-CoV-2 Delta variant mRNA encoding the SARS-CoV-2 spike glycoprotein RBD induces the production of antibodies that bind to the SARS-CoV-2 RBD in mice

DETAILS

Inchi: InChI=1S/C83H155N3O16/c1-10-18-26-30-48-72(44-22-14-5)80(91)99-68-38-34-64-95-76(87)52-60-85(61-53-77(88)96-65-35-39-69-100-81(92)73(45-23-15-6)49-31-27-19-11-2)58-42-56-84(9)57-43-59-86(62-54-78(89)97-66-36-40-70-101-82(93)74(46-24-16-7)50-32-28-20-12-3)63-55-79(90)98-67-37-41-71-102-83(94)75(47-25-17-8)51-33-29-21-13-4/h72-75H,10-71H2,1-9H3
Purity: ≥95%
Raptas: Product Type|Biochemicals|Lipids||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Lipid-Based Drug Delivery|Cationic Lipids (Ionizable)|Branched Tail||Research Area|Lipid-Based Drug Delivery|Cationic Lipids (Ionizable)|Multi-Tail Non-Disulfide||Research Area|Lipid-Based Drug Delivery|Cationic Lipids (Ionizable)|Polymeric/Dendrimer
Smiles: CN(CCCN(CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O)CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O)CCCN(CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O)CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O
Inchikey: ZURFHHPIXJDDLQ-UHFFFAOYSA-N
Cas Number: 2735814-23-8
Formulation: A solution in methyl acetate
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C83H155N3O16
Formula Weight: 1451.2
Shelf Life Days: 1095