3012272-50mg 3012272-10mg
CH 223191
Biogems
DESCRIPTION
CH 223191 is a specific and potent antagonist to the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is involved in drug and xenobiotic metabolism. Unlike other AhR antagonists, it does not react with the estrogen receptor and is observed to effect AhR-dependent reporter gene expression in human, mouse, rat, and guinea pig cell lines. CH223191 is reported to exhibit AHR-independent pro-proliferative properties.
DETAILS
- Purity: ≥95%
- Synonyms: AhR Antagonist, CH223191, AGN-PC-0KP4EW, Aryl hydrocarbon receptor antagonist
- Cas Number: 301326-22-7
- References: Zhao, B., DeGroot, D. E., Hayashi, A., He, G., & Denison, M. S. (2010). CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.Toxicological Sciences, 117(2), 393-403. Choi, E. Y., Lee, H., Dingle, R. C., Kim, K. B., & Swanson, H. I. (2012). Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor. Molecular pharmacology, 81(1), 3-11. Yoshida, T., Katsuya, K., Oka, T., Koizumi, S. I., Wakita, D., Kitamura, H., & Nishimura, T. (2012). Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells. Biomedical research, 33(2), 67-74.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide
- Molecular Weight: 333.4
- Molecular Formula: C19H19N5O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C