mouse monoclonal IgG2a; GRK 5 Antibody (D-9) is an IgG2a κ mouse monoclonal GRK 5 antibody (also designated GRK5 antibody, or GPRK5 antibody) that detects the GRK 5 protein of mouse, rat and human origin by WB, IP, IF and ELISA. GRK 5 Antibody (D-9) is available as both the non-conjugated anti-GRK 5 antibody form, as well as multiple conjugated forms of anti-GRK 5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.