E1945Hu
Scientist.com Supplier
Human Semaphorin 5A, SEMA5A ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
DETAILS
- Gene Id: 9037
- Uniprot: Q13591
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.02ng/ml
- Detection Range: 0.05-10ng/ml
- Detection Method: ELISA
- Species Reactivity: Human