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E1945Hu

Human Semaphorin 5A, SEMA5A ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

DETAILS

  • GeneID: 9037
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 120,615
  • Synonyms: Sema F;SEMA5A;Semaphorin-5A;Semaphorin-F
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: SEMA5A
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.02ng/ml
  • Target Protein: SEMA5A
  • Detection Range: 0.05-10ng/ml
  • Full Product Name: Semaphorin 5A
  • Standard Solution: 12.8ng/ml
  • UniProt Accession: Q13591